INTERNAL ASSESSMENT

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Clinical Complexity in Neurodegenerative Diseases - Case Series

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INTRODUCTION The term neuro - referring the cells of brain /neurons, Degeneration- deterioration and loss of function in the cells of a tissue or organ. These disorders are an umbrella term for a spectrum of diseases that can cause symptoms ranging from mood disturbances to dementia, involuntary movements, and cognitive decline that affect daily life. The lack of clear criteria for defining neurodegenerative disorders means that there is a wide variety of etiologies and pathophysiology to understand the clinical, pathological, molecular pathways, and therapeutic targets in management. This creates a broad scope for future research and treatment advancements. This can make it challenging to diagnose and treat these diseases effectively. However, researchers are working to better understand the underlying mechanisms of neurodegenerative disorders, which could lead to more effective treatments in the future. Neurodegenerative disorders can impact many different facets of functioning, ...
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A 70 yo Female with Neck Muscle Stiffness and Loss of Speech

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A 70 year old female came with complaints of neck muscle stiffness and unable to speak. HISTORY OF PRESENT ILLNESS: Patient was apparently asymptomatic 7 yrs back. Then she developed pain in right shoulder for which she was managed conservatively. 5 yrs ago, she developed weakness and giddiness and was diagnosed with HTN. Since 5 yrs, she developed pain in both lower limbs. PAST HISTORY: k/c/o HTN No history of DM. No history of TB. No history of Bronchial asthma. PERSONAL HISTORY: Diet: Mixed Appetite: Decreased Adequate sleep Bowel & bladder movements: Normal and Regular TREATMENT HISTORY: 1. TAB. ATENOLOL 25mg  2. TELMA-40  3. TAB. ACECLOPHENAC 4. TAB. PREDNISOLONE 5mg GENERAL EXAMINATION: Pt. is conscious Pallor is seen No icterus No cyanosis No clubbing No lymphadenopathy No pedal edema                                                   ...
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28M painful polyneuropathy, skin lesions and recurrent quadriparesis, alcoholism

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A 28 yr old male came with chief complaints of: - Weakness of both lower limbs since 15 days - multiple ulcers all over the body since 5 days HOPI: Pt. was apparently asymptomatic 15 days back, then he noticed weakness in both lower limbs when he was trying to wake up in the morning, which was sudden in onset, gradually progressive, associated with b/l limb pains.  H/o difficulty in climbing stairs, standing from sitting position. No h/o difficulty in combing, wearing T shirt, buttoning/unbuttoning. H/o high grade, intermittent fever since 5 days. Associated with chills, generalized weakness. H/o ulcers all over the body since 5 days, initially blisters, later ruptured. No h/o difficulty in coitus Patient then went to local RMP, where he was given Diclofenac and Monocef injections for 3 days.   PAST HISTORY: H/o similar complaints of weakness of both lower limbs 4 times in the past - diagnosed as ?hypokalemic periodic paralysis N/k/c/o DM, HTN, CAD, CVD, epilepsy, thyroid...
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